Publications

• Chauchat L, Guerin C, Kaluzhny Y, Renard JP. Comparison of In Vitro Corneal Permeation and In Vivo Ocular Bioavailability in Rabbits of Three Marketed Latanoprost Formulations. Eur J Drug Metab Pharmacokinet. 2023 Nov;48(6):633-645. doi: 10.1007/s13318-023-00853-5. Epub 2023 Sep 8. PubMed PMID: 37682463; PubMed Central PMCID: PMC10624750.

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• Markus J, Kaluzhny Y, Jackson GR, Kearney P, Letasiova S, Klausner M, Armento A. Development and validation of in vitro human inhalation toxicity tests for volatile liquids, mists, and sprays. European Respiratory Journal. 2023 October; 62(S67):2968. doi: 10.1183/13993003.congress-2023.PA2968.

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• Pellevoisin C, Markus J, Kaluzhny Y, Letasiova S, Klausner M, Ayehunie S. Human-relevant 3D models for in vitro inhalation toxicology studies. Toxicology letters. 2023 September; 384(S1):S61. doi: https://doi.org/10.1016/S0378-4274(23)00415-0.

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• Wallace J, Jackson GR, Kaluzhny Y, Ayehunie S, Lansley AB, Roper C, Hayden PJ. Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing. Toxicol Sci. 2023 Jul 28;194(2):178-190. doi: 10.1093/toxsci/kfad058. PubMed PMID: 37280087.

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• Bauer A, Klassa S, Herbst A, Maccioni C, Abhamon W, Segueni N, Kaluzhny Y, Hunter MC, Halin C. Optimization and Characterization of Novel ALCAM-Targeting Antibody Fragments for Transepithelial Delivery. Pharmaceutics. 2023 Jun 27;15(7). doi: 10.3390/pharmaceutics15071841. PubMed PMID: 37514028; PubMed Central PMCID: PMC10385607.

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• Kaluzhny Y, Finelli J, Stevens Z, Armento A, Ayehunie S. Development of an in vitro 3D Human Kidney Proximal Tubular Epithelial Tissue Model. Society of Toxicology annual meeting. 2023 March; Nashville, TN, USA.

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• Ayehunie S, Holm C, Sazer D, Frare M, Armento A, Kaluzhny Y. Bioengineering of Novel Organotypic 3D Human Liver/Hepatocyte Tissue Model for Drug-Induced Liver Injury/Toxicity Studies. Toxicology letters. 2023 September.

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• Pellevoisin C, Landry T, Klausner M, Armento A, Kaluzhny Y, Ayehunie S. In Vitro Evaluation of Local Tolerance of Vaginal Formulations and Medical Devices with a 3D Human Vaginal Epithelial Model. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2023 March.

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• Letasiova S, Hudecova L, Markus J, Kaluzhny Y, Adriaens E, Klausner M. EpiOcularTMtime-to-toxicity test method for eye hazard subcategorization. Toxicology letters. 2023 September; 384(1):S123. doi: https://doi.org/10.1016/S0378-4274(23)00549-0.

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• Kaluzhny Y, Kinuthia M, Klausner M, Armento A. Evaluating ocular side effects of systemic medications utilizing the in vitro reconstructed human corneal epithelial tissue model. Toxicology letters. 2022 September; 368(S195). doi: 10.1016/j.toxlet.2022.07.531.

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• Markus J, Kaluzhny Y, Jackson GR, Gabriel O, Letasiova S, Klausner M, Kearney P, Armento A, Hudecova L. Development and evaluation of in vitro inhalation model to predict acute respiratory toxicity of mists and volatile liquids. Toxicology letters. 2022 September; 368.

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• Kaluzhny Y, Klausner M. In vitro reconstructed 3D corneal tissue models for ocular toxicology and ophthalmic drug development. In Vitro Cell Dev Biol Anim. 2021 Feb;57(2):207-237. doi: 10.1007/s11626-020-00533-7. Epub 2021 Feb 5. Review. PubMed PMID: 33544359.

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• Kaluzhny Y. Corneal Injuries of Different Origin: Predictive Performance of the 3D Human Corneal Epithelial Tissue Models. Toxicology letters. 2020 October; 331(S9). doi: 10.1016/j.toxlet.2020.05.050.

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• Kaluzhny Y, Kinuthia MW, Lapointe AM, Truong T, Klausner M, Hayden P. Oxidative stress in corneal injuries of different origin: Utilization of 3D human corneal epithelial tissue model. Exp Eye Res. 2020 Jan;190:107867. doi: 10.1016/j.exer.2019.107867. Epub 2019 Nov 6. PubMed PMID: 31705899.

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• Kaluzhny Y, Kinuthia MW, Truong T, Lapointe AM, Hayden P, Klausner M. New Human Organotypic Corneal Tissue Model for Ophthalmic Drug Delivery Studies. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2880-2898. doi: 10.1167/iovs.18-23944. PubMed PMID: 30025134.

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• Smolicek I, Kinuthia M, Truong T, Hayden PJ, Klausner M, Kaluzhny Y. In vitro reconstructed human corneal tissue model: Applications to corneal oxidative stress, dry eye, and ophthalmic drug delivery. Toxicology letters. 2017 October; 280.

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• Kaluzhny Y, Kinuthia M, Gremilogianni A, Plotkin A, Megkoulas N, Hayden P, Klausner M. An in vitro reconstructed normal human corneal tissue model: Applications to dry eye, wound healing, and ophthalmic drug delivery. Toxicology letters. 2016 September; 258.

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• Kaluzhny Y, Kandárová H, d'Argembeau-Thornton L, Kearney P, Klausner M. Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model. J Vis Exp. 2015 Aug 23;(102):e52979. doi: 10.3791/52979. PubMed PMID: 26325674; PubMed Central PMCID: PMC4692559.

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• Kaluzhny Y, Kandárová H, Handa Y, DeLuca J, Truong T, Hunter A, Kearney P, d'Argembeau-Thornton L, Klausner M. The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment. Altern Lab Anim. 2015 May;43(2):101-27. doi: 10.1177/026119291504300205. PubMed PMID: 25995013.

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• Hayden PJ, Bachelor M, Ayehunie S, Letasiova S, Kaluzhny Y, Klausner M, Kandarova H. Application of MatTek In Vitro Reconstructed Human Skin Models for Safety, Efficacy Screening, and Basic Preclinical Research. Applied in vitro toxicology. 2015; 1(3):226. doi: 10.1089/aivt.2015.0012.

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• Kandarova H, Letasiova S, Kaluzhny Y, Hayden PJ, Klausner M. Analysis of the validated EpiDerm skin corrosion test (EpiDerm-SCT) and prediction model for sub-categorization according to the UN-GHS and EU-CLP. Toxicology letters. 2014 September; 229.

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• Kaluzhny Y, Kandarova H, D"Arguembeau-Thronton L, DeLuca J, Hayden PJ, Hunter A, Truong T, Klausner M. Development and optimization of the epiocular eye irritation test (EpiOcular EIT) for solid materials addressing the EU cosmetic legislation and reach. Toxicology letters. 2014 September; 229.​

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• Kaluzhny Y, Miriam KW, d’Argembeau-Thornton L, Klausner M. In Vitro Phototoxicity Screening Assay for Systemically Administered Pharmaceuticals Using a Reconstructed Skin Model EpiDerm. The Society of Toxicology. 2013 March; San Antonio, TX, United States.

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• Pfannenbecker U, Bessou-Touya S, Faller C, Harbell J, Jacob T, Raabe H, Tailhardat M, Alépée N, De Smedt A, De Wever B, Jones P, Kaluzhny Y, Le Varlet B, McNamee P, Marrec-Fairley M, Van Goethem F. Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation. Toxicol In Vitro. 2013 Mar;27(2):619-26. doi: 10.1016/j.tiv.2012.11.007. Epub 2012 Nov 16. PubMed PMID: 23159500.

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• Letasiova S, Hayden PJ, Kaluzhny Y, Armento A, Karetsky V, Kubilus J, Ayehunie S, Kandarova H, Klausner M. Use of 3D tissue models (EpiDerm, EpiAirway) for nanotoxicology applications. 48th Congress of the European-Societies-of-Toxicology (EUROTOX); Toxicology Letters 211:S42-S42. 2012 June; Stockholm, Sweden.

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• Kandarova H, Kaluzhny Y, D'Argembeau-Thornton L, Hayden PJ, Klausner M. Human corneal full thickness-eye irritation test (EpiOcular hCFT-EIT) vs. BCOP assay. Toxicology letters. 2012 June; 211(S111). doi: 10.1016/j.toxlet.2012.03.414.

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• Letasiova S, Hayden P, Kaluzhny Y, Armento A, Karetsky V, Kandarova H, Klausner M. Use of 3D tissue models (EpiDerm, EpiAirway) for nanotoxicology applications. Toxicology letters. 2012 June; 211(S42). doi: 10.1016/j.toxlet.2012.03.174.

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• Kaluzhny Y, Kandárová H, Hayden P, Kubilus J, d'Argembeau-Thornton L, Klausner M. Development of the EpiOcular(TM) eye irritation test for hazard identification and labelling of eye irritating chemicals in response to the requirements of the EU cosmetics directive and REACH legislation. Altern Lab Anim. 2011 Sep;39(4):339-64. doi: 10.1177/026119291103900409. PubMed PMID: 21942547.

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• Kaluzhny Y, Hayden PJ, Kandarova H, Letasiova S, Armento A, DeLuca J, Karetsky V, Klausner M. Genotoxicity testing using the micronucleus and comet assays in normal human cell based 3D epithelial models. Toxicology letters. 2011 August; 205.

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• Hayden PJ, Armento A, Jackson GR, Kaluzhny Y, Klausner M. Utilization Of The Comet Assay For Assessment Of Chemical Genotoxicity Potential In The EpiAirway™ In Vitro Human Airway Model. American Thoracic Society 2011 International Conference. 2011 May; Denver, CO, United States.

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• Kaluzhny Y, Letasiova S, Hayden PJ, Bolmarcich J, Jackson G, Klausner M. Drug metabolizing enzyme activity of in vitro human dermal (EpiDerm (TM)) and airway (EpiAirway (TM)) epithelial models: Relationship to genotoxicity of chemicals as determined by in vitro skin micronucleus assays. Toxicology letters. 2009 September; 189.

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• Letasiova S, Kaluzhny Y, Kandarova H, Klausner M, Jackson G, Kubilus J. EpiOcular tissue model protocols for (1) REACH ocular irritation screening and (2) ultra-mild eye care cosmetics. Toxicology letters. 2009 September; 189.

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• Mun GC, Aardema MJ, Hu T, Barnett B, Kaluzhny Y, Klausner M, Karetsky V, Dahl EL, Curren RD. Further development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay. Mutat Res. 2009 Mar 17;673(2):92-9. doi: 10.1016/j.mrgentox.2008.12.004. Epub 2009 Jan 9. PubMed PMID: 19167515.

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• Hu T, Kaluzhny Y, Mun GC, Barnett B, Karetsky V, Wilt N, Klausner M, Curren RD, Aardema MJ. Intralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay. Mutat Res. 2009 Mar 17;673(2):100-8. doi: 10.1016/j.mrgentox.2008.12.003. Epub 2009 Jan 9. PubMed PMID: 19167513.

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• Hayden P, Kubilus J, Ayehunie S, Kaluzhny Y, Kandarova H, Kearney P, Klausner M, Sheasgreen J. Commercial Production of In Vitro Human Epithelial Models at MatTek Corporation: A Survey of Available Models and Applications. In vitro cellular & developmental biology. Animal. 2009 March; 45.

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• Kandarova H, Raabe H, Chua G, Klausner M, Kubilus J, Hayden P, Ayehunie S, Kaluzhny Y, Curren R, Sheasgreen J. In vitro skin corrosion test: Evidence of long term reproducibility and reliability for a regulatory accepted method. Toxicology letters. 2007 October; 172. doi: 10.1016/j.toxlet.2007.05.232.

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• Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR. Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1095-104. doi: 10.1152/ajpheart.01009.2005. Epub 2006 Oct 20. PubMed PMID: 17056665.

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• Kaluzhny Y, Kubilus J, Klausner M. Reconstructed human skin model to study melanoma at different stages of progression. The Society of Investigative Dermatology annual meeting. The Journal of Investigative Dermatology. 2005; 124(4).

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• Kaluzhny Y, Ravid K. Role of apoptotic processes in platelet biogenesis. Acta Haematol. 2004;111(1-2):67-77. doi: 10.1159/000074487. Review. PubMed PMID: 14646346.

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• Bartunek J, Croissant JD, Kaluzhny Y, Lee IW, De Bruyne B, Wijns W, Penicka M, Vanderheyden M, Heyndrickx G. Biologic ex vivo cardiac specification of adult bone marrow-derived mesenchymal stem cells and cardiac repair of the chronically infarcted myocardium. The American Journal of Cardiology. 15th Annual Transcatheter Cardiovascular Therapeutics Symposium; 2003 September; Washington, DC, United States. Elsevier; c2003.

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• Kaluzhny Y, Hechler B, Lu J, Nguyen HG, Cataldo LM, Ravid K. A selective effect of Mpl ligand on mRNA stabilization during megakaryocyte differentiation. FEBS Lett. 2002 Sep 11;527(1-3):279-83. doi: 10.1016/s0014-5793(02)03230-1. PubMed PMID: 12220674.

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• Kaluzhny Y, Yu G, Sun S, Toselli PA, Nieswandt B, Jackson CW, Ravid K. BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation. Blood. 2002 Sep 1;100(5):1670-8. doi: 10.1182/blood-2001-12-0263. PubMed PMID: 12176887.

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• Zhang Y, Sun S, Wang Z, Thompson A, Kaluzhny Y, Zimmet J, Ravid K. Signaling by the Mpl receptor involves IKK and NF-kappaB. J Cell Biochem. 2002;85(3):523-35. doi: 10.1002/jcb.10141. PubMed PMID: 11967992.

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• Zhang Y, Sun S, Chen WC, Kaluzhny Y, Chinnappan D, Yu G, Ravid K. Repression of AIM-1 kinase mRNA as part of a program of genes regulated by Mpl ligand. Biochem Biophys Res Commun. 2001 Apr 6;282(3):844-9. doi: 10.1006/bbrc.2001.4635. PubMed PMID: 11401541.

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• Kaluzhny Y, Ravid K. Transcription Factors Implicated in Hematopoiesis: In Vivo Studies. In: Ravid K, Licht JD, editors. Transcription Factors: Normal and Malignant Development of Blood Cells.  Wiley Online Library: Wiley-Liss Inc.; 2000. Chapter 31; p.571-592. Available from: https://doi.org/10.1002/0471223883.ch31.

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• Kaluzhny Y, Ravid K, Poncz M. Transcription Factors Involved in Lineage-specific Gene Expression During Megakaryopoiesis. In: Ravid K, Licht JD, editors. Transcription Factors: Normal and Malignant Development of Blood Cells [Internet] Willey Online: Wiley-Liss Inc.; 2000. Chapter 3; p.31-49. Available from: https://doi.org/10.1002/0471223883.ch3.

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• Sun S, Kaluzhny Y, Ravid K. Ectopic expression of the Aspergillus nidulans mitotic inducer, nimA kinase, in megakaryocytes: effect on polyploidization. Exp Hematol. 1999 Apr;27(4):594-604. doi: 10.1016/s0301-472x(98)00079-4. PubMed PMID: 10210317.

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• Kaluzhny Y, Kuri-Harcuch W, SchermerJ A. An in vitro model for assaying growth promoting activity of cultured epidermal allografts. The Society of Investigative Dermatology annual meeting. The Journal of Investigative Dermatology. 1992; 100(569).